ELISA Substrates and Reagents
Genscript Corporation 4-1BB/TNFRSF9 hFc ChimeraBiot
4-1BB is also known as CD137 is a type 2 transmembrane glycoprotein receptor belonging to the TNF superfamily CD137 can be expressed by activated T cells but to a larger extent on CD8 than on CD4 T cells In addition CD137 expression is found on dendritic cells B cells follicular dendritic cells natural killer cells granulocytes and cells of blood vessel walls at sites of inflammation
ABclonal Technology p-RPS6-S235/236
Ribosomes the organelles that catalyze protein synthesis consist of a small 40S subunit and a large 60S subunit Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins This gene encodes a cytoplasmic ribosomal protein that is a component of the 40S subunit The protein belongs to the S6E family of ribosomal proteins It is the major substrate of protein kinases in the ribosome with subsets of five C-terminal serine residues phosphorylated by different protein kinases Phosphorylation is induced by a wide range of stimuli including growth factors tumor-promoting agents and mitogens Dephosphorylation occurs at growth arrest The protein may contribute to the control of cell growth and proliferation through the selective translation of particular classes of mRNA As is typical for genes encoding ribosomal proteins there are multiple processed pseudogenes of this gene dispersed through the genome
ABclonal Technology Phospho-NF-kB p65/RelA-T505 Rabbit pAb
NF-kappa-B is a ubiquitous transcription factor involved in several biological processes. It is held in the cytoplasm in an inactive state by specific inhibitors. Upon degradation of the inhibitor, NF-kappa-B moves to the nucleus and activates transcription of specific genes. NF-kappa-B is composed of NFKB1 or NFKB2 bound to either REL, RELA, or RELB. The most abundant form of NF-kappa-B is NFKB1 complexed with the product of this gene, RELA. Four transcript variants encoding different isoforms have been found for this gene.
ABclonal Technology Phospho-Akt-S473 Rabbit pAb
The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Mutations in this gene have been associated with the Proteus syndrome. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2011]
ABclonal Technology Phospho-ErbB3/HER3-Y1289
This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases It has a neuregulin binding domain but lacks an active kinase domain so it cannot directly signal into the cell However it forms heterodimers with other EGFR family members that possess kinase activity activating pathways that regulate cell proliferation and differentiation Gene amplification or overexpression is observed in various cancers including prostate bladder and breast tumors Alternate splice variants of this gene encode different isoforms one of which lacks the intermembrane region and is secreted to modulate the activity of the membrane-bound form Additional splice variants have been identified but not fully characterized
ABclonal Technology Phospho-GATA1-S310 Rabbit pAb
This gene encodes a protein which belongs to the GATA family of transcription factors. The protein plays an important role in erythroid development by regulating the switch of fetal hemoglobin to adult hemoglobin. Mutations in this gene have been associated with X-linked dyserythropoietic anemia and thrombocytopenia.
ABclonal Technology Phospho-EEF2K-S366 Rabbit pAb
This gene encodes a highly conserved protein kinase in the calmodulin-mediated signaling pathway that links activation of cell surface receptors to cell division. This kinase is involved in the regulation of protein synthesis. It phosphorylates eukaryotic elongation factor 2 (EEF2) and thus inhibits the EEF2 function. The activity of this kinase is increased in many cancers and may be a valid target for anti-cancer treatment.
Genscript Corporation CEACAM-5/CD66eBiotin His
Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5) was identified as a metastatic driver CEACAM5 overproduction enriched for an epithelial gene expression pattern and facilitated tumor outgrowth at metastatic sites Tissues from patients with metastatic breast cancer confirmed elevated levels of CEACAM5 in lung metastases relative to breast tumors and an inverse correlation between CEACAM5 and the mesenchymal marker vimentin was demonstrated
Cayman Chemical DecorIn Long Isoformhumn1mg
Source: Recombinant human C-terminal His-tagged decorin expressed in HEK293 cells • Amino acids: 17-359 • MW: 39.4 kDa
Abcam ELISA Accessory Pack
ELISA Accessory Pack
The product is subject to the following: Abcam Restricted Use Statement
Cayman Chemical O-Phospho-L-TyrosIn 100mg
A phosphorylated form of L-tyrosine; used in studies of tyrosine phosphorylation; has been used in affinity chromatography to purify IgG
ABclonal Technology Phospho-CDK1-T161 Rabbit pAb
The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is a catalytic subunit of the highly conserved protein kinase complex known as M-phase promoting factor (MPF), which is essential for G1/S and G2/M phase transitions of eukaryotic cell cycle. Mitotic cyclins stably associate with this protein and function as regulatory subunits. The kinase activity of this protein is controlled by cyclin accumulation and destruction through the cell cycle. The phosphorylation and dephosphorylation of this protein also play important regulatory roles in cell cycle control. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
ABclonal Technology Phospho-α-Synuclein-S129 Rabbit pAb
Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimers disease. Alternatively spliced transcripts encoding different isoforms have been identified for this gene.
ABclonal Technology Phospho-PEA15-S104 Rabbit pAb
This gene encodes a death effector domain-containing protein that functions as a negative regulator of apoptosis. The encoded protein is an endogenous substrate for protein kinase C. This protein is also overexpressed in type 2 diabetes mellitus, where it may contribute to insulin resistance in glucose uptake. Alternative splicing results in multiple transcript variants.
American Research Products Inc AMERICAN RESEARCH PRODUCTS INC
5000606910 RAT FABP4 COLORSTEP ELISA KIT